Tottenham have confirmed England captain Harry Kane has sustained a “significant lateral ligament injury to his left ankle”.
The 25-year-old striker suffered the injury in the 1-0 win over Manchester City in the Champions League quarter-final first leg on Tuesday.
Kane’s injury could rule him out for the rest of the 2018-19 season.
Spurs have also said England midfielder Dele Alli, 23, fractured his left hand during the same match.
A club statement said Alli will be assessed before Saturday’s home Premier League match against Huddersfield Town.